Karuma Wildlife Reserve is located in Kiryandongo District in western Uganda and is 902 metres above sea level. The Wildlife Reserve is found in a territory of conservation areas that consist of Murchison Falls National Park, Kaniyo Pabidi, Budongo Forest Reserve and Bugungu Wildlife Reserve.
The reserve under the protected areas mainly lies in Kiryandongo District, formerly under Masindi. The area was conventionally a spread-out section for large animals like buffaloes and elephants besides the smaller wildlife species.
Reserve was slowly losing its role of buffering against animal incursion from park to the surroundings and instead now seems to buffer the park against pressure from human population expansion.
There is a lot of wildlife to see there including birds, butterflies, buffaloes, antelopes, warthogs and other mammals among others.